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Formulation optimization of solid self-microemulsifying pellets for enhanced oral bioavailability of curcumin

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (5)

Solidification of self-microemulsifying drug delivery systems (SMEDDS) is one of the major trends to promote the transformation of self-microemulsion ......

The efficiency and mechanism of a new absorption enhancer, malic acid, for enhancing the oral bioavailability of docetaxel

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (5)

This study investigated the efficiency and the related mechanisms of a new absorption enhancer, DL-malic acid (MA), on the oral bioavailability of doc......

A study on distribution and stability of drugs at the interface of a scutellarin-loaded emulsion

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (7)

This work mainly studies the interfacial behaviors of scutellarin on a newly developed emulsion and establishes a three-phase distribution model. The ......

Self-assembled micelles enhance the oral delivery of curcumin for the management of alcohol-induced tissue injury

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (8)

Curcumin (CUR) shows great potential in the management of alcohol-use disorders. However, the hydrophobicity and poor oral bioavailability result in t......

Dual-modified PCL-PEG nanoparticles for improved targeting and therapeutic efficacy of docetaxel against colorectal cancer

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (8)

Polycaprolactone-poly (ethylene glycol) block copolymer (PCL-PEG) based nanoparticles were prepared for the intravenous administration of docetaxel (D......

Co-delivery of CPP decorated doxorubicin and CPP decorated siRNA by NGR-modified nanobubbles for improving anticancer therapy

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (6)

A combination of doxorubicin (DOX) and small interfering RNA (siRNA) is proven effective for the reverse of multidrug resistance. However, rapid degra......

Novel biomimetic nanostructured lipid carriers for cancer therapy: preparation, characterization, and in vitro/in vivo evaluation

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (1)

Nanostructured lipid carriers (NLC) have become a research hotspot, wherein cancer-targeting effects are enhanced and side effects of chemotherapy are......

In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2021; 26 (3)

Hypertension is one of the most common chronic cardiovascular disorders. Sustained-release formulations are developed to maintain drug therapeutic lev......

Preparation and in vitro/in vivo evaluation of 6-Gingerol TPGS/PEG-PCL polymeric micelles

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2020; 25 (1)

6-Gingerol, an active herbal ingredient of ginger has various bioactivities such as anti-neurodegenerative disease, anti-inflammatory and so on. The a......

Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2020; 25 (3)

Curcumin, a polyphenol compound extracted from the roots of turmeric plants, possesses anti-depressant effect by regulating the levels of neuroendocri......

Mucoadhesive buccal film containing ornidazole and dexamethasone for oral ulcers: in vitro and in vivo studies

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2019; 24 (1)

A bilayered mucoadhesive buccal film containing a combination of ornidazole (OD) and dexamethasone sodium phosphate (DEX) was prepared using solvent c......

JIF:2.35

Conjugates of TAT and folate with DOX-loaded chitosan micelles offer effective intracellular delivery ability

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2019; 24 (2)

The key for better antitumor efficacy is to improve the specificity of antitumor drugs for tumor cells and diminish their cytotoxicity to normal tissu......

JIF:2.35

Silk fibroin nanoparticles for enhanced bio-macromolecule delivery to the retina

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2019; 24 (5)

The aim of this study was to investigate intravitreal injection of silk fibroin nanoparticles (SFNs) encapsulating bio-macromolecules, achieving enhan......

JIF:2.35

Acoustic emission detection of crystallization in two forms: monohydrate and anhydrous citric acid

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2019; 24 (4)

Reliable monitoring of solution crystallization processes is important to provide further insight into process dynamics and to improve process control......

JIF:2.35

Preparation and in vivo pharmacokinetics of rhGH-loaded PLGA microspheres

期刊: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2019; 24 (4)

Recombinant human growth hormone (rhGH) therapy must be administered as a daily injection due to its short half-life. To achieve sustained release of ......

JIF:2.35

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