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Insights into adaption and growth evolution: a comparative genomics study on two distinct cattle breeds from Northern and Southern China

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

Mongolian cattle (MG, Bos taurus) and Minnan cattle (MN, Bos indicus) are two different breeds of Chinese indigenous cattle, representing North type a......

Roles of circRNAs on tumor autophagy

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

Circular RNAs (circRNAs) are a type of special noncoding RNA. circRNAs are highly stable and are found mainly in the cytoplasm. Most circRNAs are cons......

DNA methylation regulator-mediated modification patterns and tumor microenvironment characterization in gastric cancer

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 24 ()

Growing evidence implies a link between DNA methylation and tumor immunity/immunotherapy. However, the global influence of DNA methylation on the char......

ncRNAs-mediated high expression of SEMA3F correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinoma

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 24 ()

Hepatocellular carcinoma (HCC) is notorious for its poor prognosis. Increasing evidence has demonstrated that semaphorin 3F (SEMA3F) plays key roles i......

lncRNA FDNCR promotes apoptosis of granulosa cells by targeting the miR-543-3p/DCN/TGF-beta signaling pathway in Hu sheep

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 24 ()

Long non-coding RNAs (lncRNAs) regulate the development of follicles and reproductive diseases, but the mechanisms by which lncRNAs regulate ovarian f......

lncRNA MIR210HG promotes the progression of endometrial cancer by sponging miR-337-3p/137 via the HMGA2-TGF-f3/Wnt pathway

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 24 ()

Epithelial-mesenchymal transition (EMT) promotes tumorigenesis and metastasis and increases tumor tolerance to treatment intervention. Abnormal activa......

MBD2 Mediates Septic AKI through Activation of PKC eta/p38MAPK and the ERK1/2 Axis

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

Our previous study demonstrated that the methyl-CpG-binding domain protein 2 (MBD2) mediates vancomycin (VAN)-induced acute kidney injury (AKI). Howev......

ICLRBBN: a tool for accurate prediction of potential lncRNA disease associations

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

Growing evidence has elucidated that long non-coding RNAs (lncRNAs) are involved in a variety of complex diseases in human bodies. In recent years, it......

HDAC1-mediated deacetylation of HIF1 alpha prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

We intended to characterize functional relevance of microRNA (miR)-224-3p in endothelial cell (EC) apoptosis and reactive oxygen species (ROS) accumul......

Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

Glioma is the most common malignancy in the central nervous system with no immediate prospect of a cure. Comprehensive understanding on the pathogenes......

FABP4 facilitates inflammasome activation to induce the Treg/Th17 imbalance in preeclampsia via forming a positive feedback with IL-17A

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 24 ()

Preeclampsia (PE) is one of the leading causes of maternal death worldwide. Elevated fatty acid binding protein 4 (FABP4) levels have been observed in......

circFOXM1 contributes to sorafenib resistance of hepatocellular carcinoma cells by regulating MECP2 via miR-1324

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

As one of the most common malignant tumors, hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths around the world. Emerging stud......

Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

Cancer cell-derived extracellular vesicles (EVs) have been reported to promote the progression of colorectal cancer (CRC), although the regulatory mec......

lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 23 ()

Dysfunction of granulosa cells (GCs) leading to follicle atresia has been extensively studied as a major cause of premature ovarian insufficiency (POI......

Silencing LINC01021 inhibits gastric cancer through upregulation of KISS1 expression by blocking CDK2-dependent phosphorylation of CDX2

期刊: MOLECULAR THERAPY-NUCLEIC ACIDS, 2021; 24 ()

Gastric cancer remains one of the most dangerous cancers, bringing suffering and economic burden to people worldwide. Long noncoding RNAs (lncRNAs) ex......

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