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Emerging Roles of the Copper-CTR1 Axis in Tumorigenesis

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (9)

Physiologic roles of copper in metabolic homeostasis have been well established; however, whether and how copper is dysregulated in tumors and contrib......

JIF:5.125

EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (7)

In comparison with intestinal-type gastric cancer, diffuse-type gastric cancer (DGC) is more likely to recur, metastasize, and exhibit worse clinical ......

JIF:5.125

HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (12)

Cancer progression is highly dependent on the ability of cancer cell tumor formation, in which epigenetic modulation plays an essential role. However,......

JIF:5.125

TFAP4 Activates IGF2BP1 and Promotes Progression of Non-Small Cell Lung Cancer by Stabilizing TK1 Expression through m6A Modification

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (12)

Non-small cell lung cancer (NSCLC) is a well-known global health concern. TFAP4 has been reported to function as an oncogene. This study sought to inv......

JIF:5.125

CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (11)

Polycomb group proteins are often dysregulated in cancer, leading to disruption of epigenetic landscapes and acquisition of cancer hallmarks. Chromobo......

JIF:5.125

Protein Phosphatase 2A-Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere Capping

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (4)

The heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), telomeric repeat-containing RNA (TERRA), and protection of telomeres 1 (POT1) have been repo......

JIF:5.125

circ_ 0041732 Promotes Breast Cancer Progression

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (10)

Breast cancer is quite a prevalent cancer worldwide, and it is the leading cause of cancer-related deaths among female popula-tions worldwide. Increas......

JIF:5.125

Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (1)

Lymphatic metastasis is a common clinical symptom in naso-pharyngeal carcinoma (NPC), the most common Epstein-Barr virus (EBV)-associated head and nec......

JIF:5.125

Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (5)

Acidification is recognized as the predominant characteristic of the tumor microenvironment (TME) and contributes to tumor progression. However, the m......

JIF:5.125

Oncogenic Activity of Glucocorticoid Receptor beta Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (1)

Previous studies have demonstrated that glucocorticoid receptor beta (GR beta) functions as an oncoprotein, regulating the malignant phenotypes and st......

JIF:5.125

MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (11)

Recently, long noncoding RNAs (lncRNA) have been re-ported as tumor suppressors or oncogenes in colorectal cancer. This study aims to discover functio......

JIF:5.125

The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (2)

Dysregulation of Notch signaling has been implicated in cellular transformation and tumorigenesis in a variety of cancers while potential roles of MIB......

JIF:5.125

Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (4)

Breast cancer is one of the commonest malignancies in women with first occurrence and fifth mortality in the world. However, drug resistance has alway......

JIF:5.125

Circ_0001821 Affects Proliferation and the Cell Cycle in Esophageal Squamous Cell Carcinoma by Elevating BTRC-Mediated IKBA Ubiquitination

期刊: MOLECULAR CANCER RESEARCH, 2022; 20 (11)

Esophageal squamous cell carcinoma (ESCC) is a fatal human cancer featured with a tendency to metastasis and relapse. Increas-ing studies have emphasi......

JIF:5.125

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