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MiR-151b inhibits osteoblast differentiation via downregulating Msx2

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (2)

Purpose: MicroRNA-151b (miR-151b) showed altered expression in ovariectomized rat model of osteoporosis. This study established an ovariectomy-induced......

JIF:2.824

Synergistic effects of myogenic cells and fibroblasts on the promotion of engineered tendon regeneration with muscle derived cells

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Aims Tendon development requires the coordinated interaction of muscles and tendons. Muscle-derived cells (MDCs), a mixed cell population containing b......

JIF:2.824

IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (5)

Purpose Type V collagen (collagen V) is one of the important components of extracellular matrix (ECM) in pancreas. We previously reported that pre-coa......

JIF:2.824

Sema3A accelerates bone formation during distraction osteogenesis in mice

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Distraction osteogenesis (DO) is a bone regeneration technique used to treat maxillofacial disorders, fracture nonunion, and large bone defects. It is......

JIF:2.824

Extracellular vesicles from human umbilical cord mesenchymal stem cells reduce lipopolysaccharide-induced spinal cord injury neuronal apoptosis by mediating miR-29b-3p/PTEN

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (6)

Objective This study investigated the molecular mechanism of whether hUC-MSCs-EVs repressed PTEN expression and activated the PI3K/AKT pathway through......

JIF:2.824

RHOA inhibits chondrogenic differentiation of mesenchymal stem cells in adolescent idiopathic scoliosis

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (5)

Purpose The etiology of adolescent idiopathic scoliosis (AIS) remains unclear. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is im......

JIF:2.824

Fluid shear stress-induced down-regulation of microRNA-140-5p promotes osteoblast proliferation by targeting VEGFA via the ERK5 pathway

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (2)

Purpose: Fluid shear stress (FSS) plays a critical role in osteoblast proliferation. However, the role of miRNA in osteoblast proliferation induced by......

JIF:2.824

Role of Nrf2 and HO-1 in intervertebral disc degeneration

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (6)

Intervertebral disc degeneration (IDD) is a common age-related disease with clinical manifestations of lumbar and leg pain and limited mobility. The p......

JIF:2.824

Effect of bone marrow mesenchymal stem cell transplantation combined with lugua polypeptide injection on osteoarthritis in rabbit knee joint

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (4)

Purpose : This study aimed to elucidate the effect of bone marrow mesenchymal stem cell (BMSC) transplantation combined with the administration of Lug......

JIF:2.824

The protective role of glucocerebrosidase/ceramide in rheumatoid arthritis

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (6)

Objective To clarify the role of glucocerebrosidase (GBA) and Ceramide (Cer) in rheumatoid arthritis (RA). Methods GBA-expressing lentivirus were cons......

JIF:2.824

The potential role of mechanosensitive ion channels in substrate stiffness-regulated Ca2+ response in chondrocytes

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (5)

Purpose The stiffness of the pericellular matrix (PCM) decreases in the most common degenerative joint disease, osteoarthritis (OA). This study was un......

JIF:2.824

Inhibition of RhoA/MRTF-A signaling alleviates nucleus pulposus fibrosis induced by mechanical stress overload

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (1)

Purpose/Aim : Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and clinically useful drugs for IDD are unavailable. Mec......

JIF:2.824

Pigment epithelium-derived factor modulates periodontal homeostasis in mice and induces osteogenic differentiation of human periodontal ligament fibroblasts

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (5)

Aim The aim of this study was to investigate the influence of pigment epithelium-derived factor (PEDF) on periodontal homeostasis in mice and the oste......

JIF:2.824

Radial extracorporeal shock wave reduces myogenic contracture and muscle atrophy via inhibiting NF-kappa B/HIF-1 alpha signaling pathway in rabbit

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (3)

Purpose: We investigate the underlying biological effects and mechanisms of rESWT on myogenic contracture and muscle atrophy in a rabbit model of exte......

JIF:2.824

Acceleration of pelvic tissue generation by overexpression of basic fibroblast growth factor in stem cells

期刊: CONNECTIVE TISSUE RESEARCH, 2022; 63 (3)

Background: Pelvic organ prolapse (POP) is a common debilitating condition affecting approximately 30-40% of women. The FDA issued a warning about pol......

JIF:2.824

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