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TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2 (vol 81, pg 1004, 2020)

期刊: DRUG DEVELOPMENT RESEARCH, 2021; 82 (3)

Faced with the current large-scale public health emergency, collecting, sorting, and analyzing biomedical information related to the "SARS-CoV-2" shou......

Neuroprotective effect of Na+/H+ exchangers isoform-1 inactivation against 6-hydroxydopamine-induced mitochondrial dysfunction and neuronal apoptosis in Parkinson's disease models

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

Parkinson's disease (PD) is a disabling neurodegenerative disease mainly caused by degeneration of mesencephalic dopaminergic neurons in the substanti......

Tectorigenin regulates migration, invasion, and apoptosis in dexamethasone-induced human airway epithelial cells through up-regulating miR-222-3p

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

Glucocorticoids (GCs) can effectively control airway inflammation, but can also cause airway epithelial injury. Tectorigenin, a type of isoflavone iso......

Design, synthesis, and biological evaluation of 3 ',4 ',5 '-trimethoxy evodiamine derivatives as potential antitumor agents

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

A series of compounds bearing 3 ',4 ',5 '-trimethoxy module into the core structure of evodiamine were designed and synthesized. The synthesized compo......

Irigenin alleviates angiotensin II-induced oxidative stress and apoptosis in HUVEC cells by activating Nrf2 pathway

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

Endothelial dysfunction is closely related to various cardiovascular diseases. Oxidative stress and apoptosis are involved in the progress of endothel......

Azithromycin inhibited oxidative stress and apoptosis of high glucose-induced podocytes by inhibiting STAT1 pathway

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

Azithromycin (AZM) has a therapeutic effect on diabetes, but there is no report on whether AZM has a therapeutic effect on diabetic nephropathy (DN) a......

Discovery of novel indole-1,2,4-triazole derivatives as tubulin polymerization inhibitors

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

A series of novel indole-1,2,4-triazole derivatives have been designed, synthesized, and evaluated as potential tubulin polymerization inhibitors. The......

Neobavaisoflavone protects osteoblasts from dexamethasone-induced oxidative stress by upregulating the CRNDE-mediated Nrf2/HO-1 signaling pathway

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

Neobavaisoflavone (NBIF) is a flavonoid, which has a variety of pharmacological activities. However, the mechanism of NBIF in the treatment of osteopo......

HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

As an anti-tumor agent, histone deacetylases (HDACs) inhibitors have attracted wide attention. ACY1215 is a highly effective selective inhibitor of HD......

Neuroprotective mechanisms of mangiferin in neurodegenerative diseases

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

The central nervous system (CNS) regulates and coordinates an extensive array of complex processes requiring harmonious regulation of specific genes. ......

Paeonol protects melanocytes against hydrogen peroxide-induced oxidative stress through activation of Nrf2 signaling pathway

期刊: DRUG DEVELOPMENT RESEARCH, ; ()

Oxidative stress plays a pivotal role in the pathogenesis of vitiligo. Paeonol, a phenolic compound found in the root bark of Cortex Moutan, has been ......

Flufenamic acid alleviates sepsis-induced lung injury by up-regulatingCBR1

期刊: DRUG DEVELOPMENT RESEARCH, 2020; 81 (7)

Investigate the effect of flufenamic acid (FFA) on lung injury of sepsis rats. Rat sepsis model was established using cecal ligation and puncture (CLP......

Ginsenoside Rg3 attenuates ovariectomy-induced osteoporosis viaAMPK/mTORsignaling pathway

期刊: DRUG DEVELOPMENT RESEARCH, 2020; 81 (7)

Ginsenoside Rg3, a ginsenoside isolated fromPanax ginseng, can regulate autophagy via AMP-activated protein kinase/mammalian target of rapamycin (AMPK......

Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibitingPI3K/AKTpathway

期刊: DRUG DEVELOPMENT RESEARCH, 2020; 81 (8)

Background Curcumol was presented to unleash antitumor effects in a variety of cancers, including gastric cancer. However, the relevance between curcu......

Preparation, characterization, and sonodynamic antitumor effect of the folate receptor targeted FA-EN-beta-CD containing hematoporphyrin in vitro

期刊: DRUG DEVELOPMENT RESEARCH, 2020; 81 (5)

To improve water solubility, reduce phototoxicity and increase the tumor-targeting ability of hematoporphyrin (Hp) as a sonosensitizer for sonodynamic......

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