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Ctenopharyngodon idella Tollip regulates MyD88-induced NF-kappa B activation

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 123 ()

Toll-interacting protein (Tollip) and MyD88 are key components of the TLR/IL-1R signaling pathway in mammals. MyD88 is known as a universal adaptor pr......

Identification and characterization of circRNAs in the liver of blunt snout bream (Megalobrama amblycephala) infected with Aeromonas hydrophila

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 124 ()

Circular RNAs (circRNAs), a class of non-coding RNAs, play an important role in regulating various biological processes. In the present study, circRNA......

The unique structure of the zebrafish TNF-alpha homotrimer

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 122 ()

In the current study, zebrafish TNF-alpha 1 (zTNF-alpha 1) was crystallized, and the structure was analyzed. The zTNF-alpha 1 trimer is composed of th......

The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 123 ()

Vertebrate interleukin-12 (IL-12) is a heterodimeric cytokine composing of two subunits (p35 and p40). In the present study, a p35-like subunit homolo......

Comparative analysis of the miRNA-mRNA regulation networks in turbot (Scophthalmus maximus L.) following Vibrio anguillarum infection

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 124 ()

MicroRNAs could not only regulate posttranscriptional silencing of target genes in eukaryotic organisms, but also have positive effect on their target......

The Notch receptor-ligand Delta is involved in the immune response of Penaeus vannamei

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 125 ()

In the Notch signaling pathway in vertebrates and invertebrates, the ligand Delta plays crucial roles in cell proliferation, differentiation, and immu......

Identification and function of an Arasin-like peptide from Litopenaeus vannamei

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 125 ()

Antimicrobial peptides (AMPs) play an important role in the host defense system of shrimps. In this study, an Arasin-like peptide, named as LvArasin-l......

Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 125 ()

As a group of cytokines, interferons are the first line of defense in the antiviral immunity. In this study, Siberian tiger IFN-beta (PtIFN-beta) and ......

Two fibrinogen-related proteins (FREPs) in the razor clam (Sinonovacula constricta) with a broad recognition spectrum and bacteria agglutination activity

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 121 ()

Fibrinogen-related proteins (FREPs) that contain only the fibrinogen-related domain are likely involved in pathogen recognition. In this study, we ide......

Molecular characterization and biological effect of a C-type lectin receptor in Qihe crucian carp, Carassius auratus

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 121 ()

C-type lectin receptors, as the important members of pattern-recognition receptors, play the crucial roles in the innate immune system, which discrimi......

Molecular cloning and characterization of CD63 in common carp infected with koi herpesvirus

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 121 ()

CD63 is a member of the four-transmembrane-domain protein superfamily and is the first characterized tetraspanin protein. In the present study, we clo......

Viperin_sv1 promotes RIG-I expression and suppresses SVCV replication through its radical SAM domain

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 123 ()

SVCV infection is known to activate the host's innate immune responses, including the production of interferon (IFN) and interferon-stimulated genes (......

MAVS splicing variants associated with TRAF3 and TRAF6 in NF-KB and IRF3 signaling pathway in large yellow croaker Larimichthys crocea

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 121 ()

Mitochondrial antiviral signaling protein (MAVS) acts as an essential adaptor in host RIG-I-like receptors (RLRs) mediated antiviral signaling pathway......

Molecular identification of peptidoglycan recognition protein 5 and its functional characterization in innate immunity of large yellow croaker, Larimichthys crocea

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 124 ()

Fish peptidoglycan recognition proteins (PGRPs) play important roles in microbial recognition, and bacterial elimination. In the present study, a shor......

PAP1 activates the prophenoloxidase system against bacterial infection in Musca domestica

期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021; 124 ()

We previously identified three putative prophenoloxidase-activating proteinase (mdPAP1, mdPAP2, and mdPAP3) genes from housefly Musca domestica by tra......

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