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MicroRNA-33/33*inhibit the activation of MAVS through AMPK in antiviral innate immunity

期刊: CELLULAR & MOLECULAR IMMUNOLOGY, 2021; 18 (6)

Innate immunity plays a prominent role in the host defense against pathogens and must be precisely regulated. As vital orchestrators in cholesterol ho......

NLRP3 inflammasome activation and cell death

期刊: CELLULAR & MOLECULAR IMMUNOLOGY, 2021; 18 (9)

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate immune receptor protein NLRP3, adapter protein ASC, and inflammatory......

Biology and pathology of the uterine microenvironment and its natural killer cells

期刊: CELLULAR & MOLECULAR IMMUNOLOGY, 2021; 18 (9)

Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determin......

Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors

期刊: CELLULAR & MOLECULAR IMMUNOLOGY, 2021; 18 (9)

Programmed cell death protein-1 (PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen......

Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

期刊: CELLULAR & MOLECULAR IMMUNOLOGY, 2021; 18 (9)

Chimeric antigen receptor (CAR)-engineered T-cell (CAR-T) therapy has demonstrated impressive therapeutic efficacy against hematological malignancies,......

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