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Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer

期刊: CHANNELS, 2021; 15 (1)

Most of Solute carrier family-2 (SLC2) members play a key role of facilitative transporters, and glucose transporter (GLUT) proteins encoded by SLC2s ......

Database mining analysis revealed the role of the putative H+/sugar transporter solute carrier family 45 in skin cutaneous melanoma

期刊: CHANNELS, 2021; 15 (1)

Metabolic reprogramming is common in various cancers. Targeting metabolism to treat tumors is a hot research topic at present. Among them, changes in ......

17 beta-Estradiol activates Cl- channels via the estrogen receptor alpha pathway in human thyroid cells

期刊: CHANNELS, 2021; 15 (1)

Estradiol regulates thyroid function, and chloride channels are involved in the regulation of thyroid function. However, little is known about the rol......

Fast desensitization of acetylcholine receptors induced by a spider toxin

期刊: CHANNELS, 2021; 15 (1)

Nicotinic acetylcholine receptors (nAChRs) are members of the "cys-loop" ligand-gated ion channel superfamily that play important roles in both the pe......

The clinical and genetic heterogeneity analysis of five families with primary periodic paralysis

期刊: CHANNELS, 2021; 15 (1)

To explore the clinical and genetic characteristics of five families with primary periodic paralysis (PPP). We reviewed clinical manifestations, labor......

Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma

期刊: CHANNELS, 2021; 15 (1)

Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer. Many patients with hepatocellular carcinoma are diagnosed at an advanced st......

Solute carrier transporter superfamily member SLC16A1 is a potential prognostic biomarker and associated with immune infiltration in skin cutaneous melanoma

期刊: CHANNELS, 2021; 15 (1)

Melanoma is a type of cancer with a relatively poor prognosis. The development of immunotherapy for the treatment of patients with melanoma has drawn ......

Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma

期刊: CHANNELS, 2021; 15 (1)

As the most common histologic subtype of renal cancer, clear cell renal cell carcinoma (ccRCC) poses a serious threat to public health. However, there......

A pan-cancer analysis revealed the role of the SLC16 family in cancer

期刊: CHANNELS, 2021; 15 (1)

Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although the current targeted......

TRPM2 in ischemic stroke: Structure, molecular mechanisms, and drug intervention

期刊: CHANNELS, 2021; 15 (1)

Ischemic stroke has a high lethality rate worldwide, and novel treatments are limited. Calcium overload is considered to be one of the mechanisms of c......

Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking

期刊: CHANNELS, 2021; 15 (1)

The slowly activating delayed rectifier K+ current (I (Ks)) plays a key role in the repolarization of ventricular action potential in the human heart ......

Expression defect of the rare variant/Brugada mutation R1512W depends upon the SCN5A splice variant background and can be rescued by mexiletine and the common polymorphism H558R

期刊: CHANNELS, 2021; 15 (1)

Background: Mutations in SCN5A that decrease Na current underlie arrhythmia syndromes such as the Brugada syndrome (BrS). SCN5A in humans has two spli......

Bibliometric analysis of nicotinic acetylcholine receptors channel research (2000-2020)

期刊: CHANNELS, 2021; 15 (1)

To explore the research status, hotspots, and trends in research on nicotinic acetylcholine receptor (nAChR) channel. The Web of Science core collecti......

Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: Potential therapeutic targets for osteoarthritis

期刊: CHANNELS, 2021; 15 (1)

Articular cartilage consists of an extracellular matrix including many proteins as well as embedded chondrocytes. Articular cartilage formation and fu......

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