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Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-kappa B signaling pathway

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (2)

In our study, we explored the effect of astragaloside IV (AgIV) on carboplatin chemotherapy in prostate cancer cell lines in vitro and in vivo. Cell v......

Resveratrol upregulates miR-455-5p to antagonize cisplatin ototoxicity via modulating the PTEN-PI3K-AKT axis

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (3)

Resveratrol is a non-flavonoid polyphenol compound that exists in many plants, and is considered an antitoxin. This study explores the effects from th......

Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (3)

Atherosclerosis (AS) is a chronic inflammatory disease that involves cell death and endothelial dysfunction. Melatonin is an endocrine hormone with an......

Knockdown of SGLT1 prevents the apoptosis of cardiomyocytes induced by glucose fluctuation via relieving oxidative stress and mitochondrial dysfunction

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (3)

Fluctuations in the concentration of glucose in the blood is more detrimental than a constantly high level of glucose with respect to the development ......

The lncRNA TUG1 promotes cell growth and migration in colorectal cancer via the TUG1-miR-145-5p-TRPC6 pathway

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (2)

Colorectal cancer (CRC) is the third-most prevalent malignant tumor. Taurine upregulated gene 1 (TUG1), a long non-coding RNA ( lncRNA), is reportedly......

hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (2)

The early metastasis of cervical cancer is a multistep process requiring the cancer cells to adapt to the signal input from different tissue environme......

MiR-494-3p alleviates acute lung injury through regulating NLRP3 activation by targeting CMPK2

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (3)

Acute lung injury (ALI) is a severe respiratory disorder with a high rate of mortality, and is characterized by excessive cell apoptosis and inflammat......

Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial-mesenchymal transition in breast cancer cells via the miR-136-Smad3 axis

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (3)

Circular RNAs (circRNAs) are tissue-specific RNAs with a more stable structure than linear RNAs, and their association with breast cancer (BC) is poor......

Synergistic effects of autophagy inhibitors combined with cisplatin against cisplatin-resistant nasopharyngeal cancer cells

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (3)

This study explored the synergistic effects of autophagy inhibitors combined with cisplatin against cisplatin-resistant nasopharyngeal cancer cells by......

The let-7f-5p-Nme4 pathway mediates tumor necrosis factor alpha-induced impairment in osteogenesis of bone marrow-derived mesenchymal stem cells

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (4)

Although tumor necrosis factor alpha (TNF-alpha)-mediated inflammation significantly impacts osteoporosis, the mechanisms underlying the osteogenic di......

Formononetin protects against concanavalin-A-induced autoimmune hepatitis in mice through its anti-apoptotic and anti-inflammatory properties

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (2)

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that seriously threatens the health of humans globally. Formononetin (FMN) is a nat......

Blockade of anti-dsDNA ameliorates systemic lupus erythematosus in MRL/Faslpr mice through ameliorating inflammation via the PKC delta-NLRC4 axis

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (3)

Anti-double-stranded DNA (anti-dsDNA) is closely associated with the inflammatory burden in the brain after ischemic stroke. Here, we studied the infl......

Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1

期刊: BIOCHEMISTRY AND CELL BIOLOGY, 2021; 99 (2)

Abraxas brother protein 1 (ABRO1) is a subunit of the deubiquitinating enzyme BRCC36-containing isopeptidase complex and plays important roles in cell......

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