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The lncRNA PAHRF functions as a competing endogenous RNA to regulate MST1 expression by sponging miR-23a-3p in pulmonary arterial hypertension

期刊: VASCULAR PHARMACOLOGY, 2021; 139 ()

Background: Emerging evidence has shown that long non-coding RNA (lncRNA) plays important roles in the development of pulmonary arterial hypertension ......

Prenatal exercise reprograms the development of hypertension progress and improves vascular health in SHR offspring

期刊: VASCULAR PHARMACOLOGY, 2021; 139 ()

Background: Upregulation of L-type voltage-gated Ca2+ (CaV1.2) channel in the arterial myocytes is a hallmark feature of hypertension. However, whethe......

CircDIP2C ameliorates oxidized low-density lipoprotein-induced cell dysfunction by binding to miR-556-5p to induce TET2 in human umbilical vein endothelial cells

期刊: VASCULAR PHARMACOLOGY, 2021; 139 ()

Circular RNAs (circRNAs) are a group of conserved noncoding RNAs. Recent reports reveal that circRNAs play vital parts in cardiovascular system, inclu......

The lncRNA MALAT1 participates in regulating coronary slow flow endothelial dysfunction through the miR-181b-5p-MEF2A-ET-1 axis

期刊: VASCULAR PHARMACOLOGY, 2021; 138 ()

Background: Coronary slow flow (CSF) refers to coronary arteries with no obvious stenosis but have slow coronary flow without effective treatment. The......

Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration

期刊: VASCULAR PHARMACOLOGY, 2021; 138 ()

5-Hydroxytryptamine (5-HT)-dependent signaling mediated through its transporters and receptors plays important roles in chronic hypoxic pulmonary hype......

Osteogenic differentiation and calcification of human aortic smooth muscle cells is induced by the RCN2/STAT3/miR-155-5p feedback loop

期刊: VASCULAR PHARMACOLOGY, 2021; 136 ()

Background: Vascular calcification (VC) is associated with the high morbidity and mortality of cardiovascular diseases in dialysis patients and is a p......

Exosomal miR-211 contributes to pulmonary hypertension via attenuating CaMK1/PPAR-gamma axis

期刊: VASCULAR PHARMACOLOGY, 2021; 136 ()

Aim: Exsomes play a significant role in increasing pathophysiological processes by delivering their content. Recently, a variety of studies have showe......

Factor Xa inhibitor rivaroxaban suppresses experimental abdominal aortic aneurysm progression via attenuating aortic inflammation

期刊: VASCULAR PHARMACOLOGY, 2021; 136 ()

Objective: Rivaroxaban is a specific factor Xa (FXa) inhibitor for venous thromboembolism treatment. Recently, increasing evidence have reported the b......

Targeting androgen receptor in macrophages inhibits phosphate-induced vascular smooth muscle cell calcification by decreasing IL-6 expression

期刊: VASCULAR PHARMACOLOGY, 2020; 130 ()

Vascular calcification (VC) is a common complication of chronic kidney disease (CKD). However, its mechanisms remain unclear. VC, similar to atheroscl......

Indoxyl sulfate promotes the atherosclerosis through up-regulating the miR-34a expression in endothelial cells and vascular smooth muscle cells in vitro

期刊: VASCULAR PHARMACOLOGY, 2020; 131 ()

Atherosclerosis (AS) is one of the most common cardiovascular events in patients with chronic renal insufficiency (CRI). During the development of CRI......

Hdac9 inhibits medial artery calcification through down-regulation of Osterix

期刊: VASCULAR PHARMACOLOGY, 2020; 132 ()

Backgrounds: Medial artery calcification (MAC) significantly contributes to the increased cardiovascular death in patients with chronic kidney disease......

New insights into immunomodulation via overexpressing lipoic acid synthase as a therapeutic potential to reduce atherosclerosis

期刊: VASCULAR PHARMACOLOGY, 2020; 133 ()

Atherosclerosis is a systemic chronic inflammatory disease. Many antioxidants including alpha-lipoic acid (LA), a product of lipoic acid synthase (Lia......

Methylglyoxal-induced miR-223 suppresses rat vascular K-ATP channel activity by downregulating Kir6.1 mRNA in carbonyl stress

期刊: VASCULAR PHARMACOLOGY, 2020; 128 ()

The vascular ATP-sensitive K+ (K-ATP) channel composed of Kir6.1 and SUR2B subunits regulates cellular activity by coupling intermediary metabolism to......

Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF-kappa B signaling pathway in vascular smooth muscle cells

期刊: VASCULAR PHARMACOLOGY, 2020; 124 ()

Metformin (Met) can improve atherosclerosis (As). Abnormal endothelin receptors [including endothelin type A (ETA) or type B (ETB) receptor] in vascul......

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