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AmoebaContact and GDFold as a pipeline for rapid de novo protein structure prediction

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (1)

Predicting the structures of proteins from amino acid sequences is of great importance. Recently, the accuracy of de novo protein structure prediction......

An interpretable deep-learning architecture of capsule networks for identifying cell-type gene expression programs from single-cell RNA-sequencing data

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (11)

Single-cell RNA sequencing (scRNA-seq) technologies are used to characterize the heterogeneity of cells in cell types, developmental stages and spatia......

Predicting drug-protein interaction using quasi-visual question answering system

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (2)

Identifying novel drug-protein interactions is crucial for drug discovery. For this purpose, many machine learning-based methods have been developed b......

Exploring the limit of using a deep neural network on pileup data for germline variant calling

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (4)

Single-molecule sequencing technologies have emerged in recent years and revolutionized structural variant calling, complex genome assembly and epigen......

An interpretable mortality prediction model for COVID-19 patients

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (5)

The sudden increase in COVID-19 cases is putting high pressure on healthcare services worldwide. At this stage, fast, accurate and early clinical asse......

Direct steering of de novo molecular generation with descriptor conditional recurrent neural networks

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (5)

Deep learning has acquired considerable momentum over the past couple of years in the domain of de novo drug design. Here, we propose a simple approac......

Complex sequential understanding through the awareness of spatial and temporal concepts

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (5)

Understanding sequential information is a fundamental task for artificial intelligence. Current neural networks attempt to learn spatial and temporal ......

A novel machine learning framework for automated biomedical relation extraction from large-scale literature repositories

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (6)

A lot of scientific literature is unstructured, which makes extracting information for biomedical databases difficult. Hong and colleagues show that a......

Augmenting vascular disease diagnosis by vasculature-aware unsupervised learning

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (6)

Vascular disease is one of the leading causes of death and threatens human health worldwide. Imaging examination of vascular pathology with reduced in......

Finding key players in complex networks through deep reinforcement learning

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (6)

Finding an optimal set of nodes, called key players, whose activation (or removal) would maximally enhance (or degrade) a certain network functionalit......

Towards a new generation of artificial intelligence in China

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (6)

Artificial intelligence has become a main driving force for a new round of industrial transformation around the world. Many countries including China ......

Elucidation of DNA methylation onN(6)-adenine with deep learning

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (8)

Research on DNA methylation onN(6)-adenine (6mA) in eukaryotes has received much recent attention. Recent studies have generated a large amount of 6mA......

A unified framework for integrative study of heterogeneous gene regulatory mechanisms

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (8)

Gene expression is regulated by a variety of mechanisms, which have been difficult to study in a unified way. The authors propose a flexible framework......

Iterative transfer learning with neural network for clustering and cell type classification in single-cell RNA-seq analysis

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (10)

Clustering and cell type classification are important steps in single-cell RNA-seq (scRNA-seq) analysis. As more and more scRNA-seq data are becoming ......

Embodied intelligence weaves a better future

期刊: NATURE MACHINE INTELLIGENCE, 2020; 2 (11)

Microrobots can interact intelligently with their environment and complete specific tasks by well-designed incorporation of responsive materials. Rece......

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