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Clinical Utility of Eribulin Mesylate in the Treatment of Breast Cancer: A Chinese Perspective

期刊: BREAST CANCER-TARGETS AND THERAPY, 2021; 13 ()

Eribulin mesylate, a synthetic derivative of the anti-mitotic agent halichondrin B, has a unique tubulin-based mechanism of action that is distinct fr......

Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways Targeted by Xihuang Pill in the Treatment of Breast Cancer

期刊: BREAST CANCER-TARGETS AND THERAPY, 2020; 12 ()

Purpose: The compound traditional Chinese medicine Xihuang pill (XHP) has been adopted to treat breast cancer (BC) for centuries, but its specific mec......

The Predictive Effect of the 8th AJCC Pathological Prognostic Staging on the Benefit of Postmastectomy Radiotherapy in N2/N3 Breast Cancer

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Background: The role of the 8th American Joint Committee on Cancer (AJCC) pathological prognostic staging (PPS) on treatmentdecision making of breast ......

Development and Validation of an MRI Radiomics-Based Signature to Predict Histological Grade in Patients with Invasive Breast Cancer

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Background: Histological grade is an important factor in the overall prognosis of patients with invasive breast cancer. Therefore, the non-invasive as......

Metformin Inducing the Change of Functional and Exhausted Phenotypic Tumor-Infiltrated Lymphocytes and the Correlation with JNK Signal Pathway in Triple-Negative Breast Cancer

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Metformin has been shown to have the potential to inhibit ......

Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is mainly treated with chemotherapy-based combination therapy......

Establishment and Validation of a Model for Disease-Free Survival Rate Prediction Using the Combination of microRNA-381 and Clinical Indicators in Patients with Breast Cancer

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Objective: We have found that miR-381 can regulate the proliferation of breast cancer cells by regulating TWIST protein, it can serve as a potential m......

The Involvement of Insulin-Like Growth Factor 2 Messenger Ribonucleic Acid-Binding Protein 2 in the Regulation of the Expression of Breast Cancer-Related Genes

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Aim: This study investigated the role and mechanism of insulin-like growth factor 2-IGF2BP2 in breast cancer.Methods: IGF2BP2 is overexpressed in MDA-......

Predictive and Prognostic Value of TRIM58 Protein Expression in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Introduction: Tripartite motif-containing protein (TRIM) family members play crucial roles in carcinogenesis and chemotherapy resistance. In this stud......

Chloride Intracellular Channel 1 is a Potential Biomarker for Breast Cancer

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Purpose: Multiple reports have demonstrated that highly expressed chloride intracellular channel 1 (CLIC1) exists in a range of malignant tumors and i......

Ovo Like Zinc Finger 2 (OVOL2) Suppresses Breast Cancer Stem Cell Traits and Correlates with Immune Cells Infiltration

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Background: Breast cancer stem cells (BCSCs) are associated with tumor initiation, invasion, metastasis and drug resistance. It is known that many pro......

Whole Genome Sequencing of Single-Circulating Tumor Cell Ameliorates Unraveling Breast Cancer Heterogeneity

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Objective: Because tumor tissues are most frequently heterogeneous and hard to characterize, the resulting therapeutic strategy could be misled. The m......

Real-World Outcome and Prognostic Factors Among HER2-Positive Metastatic Breast Cancer Patients Receiving Pyrotinib-Based Therapy A Multicenter Retrospective Analysis

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Purpose: To explore the efficacy, safety, and potential factors influencing efficacy and outcome of pyrotinib-based therapy in human epidermal growth ......

Economic Evaluation of Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer in the United States

期刊: BREAST CANCER-TARGETS AND THERAPY, 2022; 14 ()

Purpose: Recently, the DESTINY-Breast04 trial revealed that significant benefits in both overall survival (OS) and progression-free survival (PFS) in ......

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