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Visible-Light-Promoted Synthesis of alpha-CF2H-Substituted Ketones by Radical Difluoromethylation of Enol Acetates

期刊: ORGANIC LETTERS, 2021; 23 (2)

An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of alpha-CF2H-substituted ketones has bee......

Nucleophilic Migratory Cyclopropenation of Activated Alkynes: A Nonmetal Approach to Unbiased Cyclopropenes

期刊: ORGANIC LETTERS, 2021; 23 (7)

An unprecedented reductive [2 + 1] annulation of a-keto esters with alkynones mediated by P(NMe2)(3) is described. Although this nonmetal cyclopropena......

Access to alpha-Cyano Carbonyls Bearing a Quaternary Carbon Center by Reductive Cyanation

期刊: ORGANIC LETTERS, 2021; 23 (7)

Reductive cyanation of tertiary alkyl bromides using electrophilic cyanating reagent and zinc reductant was developed, providing various alpha-cyano k......

Merging Photoredox/Nickel Catalysis for Cross-Electrophile Coupling of Aziridines with Pyridin-1-ium Salts via Dearomatization

期刊: ORGANIC LETTERS, 2021; 23 (9)

Merging photoredox/nickel catalysis enabling the cross-electrophile coupling of aziridines with pyridin-1-ium salts involving dearomatization for the ......

A BBE-like Oxidase, AsmF, Dictates the Formation of Naphthalenic Hydroxyl Groups in Ansaseomycin Biosynthesis

期刊: ORGANIC LETTERS, 2021; 23 (9)

Ansaseomycins are ansamycin-type natural products produced through expression of the asm gene cluster in a heterologous host. A rare berberine bridge ......

Visible-Light-Induced Intermolecular Oxyimination of Alkenes

期刊: ORGANIC LETTERS, 2021; 23 (9)

An intermolecular vicinal O-N difunctionalization reaction of olefins with oxime esters through energy transfer catalysis has been developed.

Palladium-Catalyzed Desymmetric Intermolecular C-N Coupling Enabled by a Chiral Monophosphine Ligand Derived from Anthracene Photodimer

期刊: ORGANIC LETTERS, 2021; 23 (14)

The development of chiral ligands with privileged scaffolds plays an important role in transition-metal-catalyzed asymmetric reactions. Herein we pres......

Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a pi-Acceptor Biphosphoramidite Ligand

期刊: ORGANIC LETTERS, 2021; 23 (15)

The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformyl......

Iron-Catalyzed Highly Enantioselective Addition of Silyl Enol Ethers to alpha,beta-Unsaturated 2-Acyl Imidazoles

期刊: ORGANIC LETTERS, 2021; 23 (17)

A chiral Fe-II(N4) complex (N4 = (R,R)-N,N'-bis(2-isopropylquinolin-8-yl)-1,2-diphenylethane-1,2-diamine) was developed for the asymmetric conjugate a......

Cobalt-Catalyzed Isocyanide-Based Three-Component Cascade for the Synthesis of Quinazolines

期刊: ORGANIC LETTERS, 2021; 23 (17)

A Co-catalyzed cyclization reaction of isocyanides, azides, and amines to access quinazoline derivatives was described. This protocol features a high ......

Sequential Addition of Amines to Nitrile and Carbon-Carbon Multiple Bond: A Route to 7-Amino-5H-dibenzo[c,e]azepines

期刊: ORGANIC LETTERS, 2021; 23 (17)

A rare earth metal-catalyzed sequential inter- and intramolecular C-N bond formation of 2-nitrile-2'-alkenyl-(alkynyl) biphenyls with amines has been ......

Kinetically Controllable Pd-Catalyzed Decarboxylation Enabled [5+2] and [3+2] Cycloaddition toward Carbocycles Featuring Quaternary Carbons

期刊: ORGANIC LETTERS, 2021; 23 (2)

A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic c......

Fe(OTf)(3)- and gamma-Cyclodextrin-Catalyzed Hydroamination of Alkenes with Carbazoles

期刊: ORGANIC LETTERS, 2021; 23 (2)

A Fe(OTf)(3)- and gamma-cyclodextrin catalyzed hydroamination of alkenes with carbazoles is demonstrated. This biomimetic-catalyst-oriented sustainabl......

Palladium/Norbornene Catalyzed ortho Amination/Cyclization of Aryl Iodide: Process to 3-Methyl-indole Derivates and Controllable Reductive Elimination against the Second Amination

期刊: ORGANIC LETTERS, 2021; 23 (8)

A palladium/norbornene cooperative catalyzed selective C-H bond amination of aryl iodides was explored, providing an efficient tool for constructing b......

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