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Conclusions
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Conclusions

Concentric remodelling is prevalent in patients harbouring the m.3243A>G mutation and occurs in association with characteristic changes in systolic intramyocardial strains and torsion. These findings, which are closely related to urinary mutation load and disease burden, occur in patients without existing evidence of cardiac involvement, and may provide an early marker of myocardial pathology, enabling future studies of pathogenesis and intervention.

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Eur Heart J Cardiovasc Imaging. 2013 July; 14(7): 650–658.
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