The identification of Egr-1 as a likely control gene in the gliotic process might open the way to understand the transcriptional mechanisms regulating glial scar production. Further dissection of the regulatory elements in this genetic pathway might present an opportunity to separate the neuroprotective from the neurosuppressive functions of reactive astrocytes. This information could lead to new approaches to modulate the time span and severity of gliosis, thus fine-tuning neuronal tissue repair and regeneration.
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Am J Pathol. 2008 July; 173(1): 68–76.
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