Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression

Baglio, SR; Lagerweij, T; Perez-Lanzon, M; Ho, XD; Leveille, N; Melo, SA; Cleton-Jansen, AM; Jordanova, ES; Roncuzzi, L; Greco, M; van Eijndhoven, MAJ; Grisendi, G; Dominici, M; Bonafede, R; Lougheed, SM; de Gruijl, TD; Zini, N; Cervo, S; Steffan, A;

Baglio, SR (reprint author), Vrije Univ Amsterdam Med Ctr, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.; Baldini, N (reprint author), Ist Ortoped Rizzoli, Via Barbiano 1-10, I-40136 Bologna, Italy.; Pegtel, DM (reprint author), Vrije Univ Amsterdam

CLINICAL CANCER RESEARCH, 2017; 23 (14): 3721

Abstract

Purpose: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regim......

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