Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drag toxicity

Sutherland, JJ; Webster, YW; Willy, JA; Searfoss, GH; Goldstein, KM; Irizarry, AR; Hall, DG; Stevens, JL

Stevens, JL (reprint author), Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA.

PHARMACOGENOMICS JOURNAL, 2018; 18 (3): 377

Abstract

Despite investment in toxicogenomics, nonclinical safety studies are still used to predict clinical liabilities for new drug candidates. Network-based......

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