Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

Shin, DS; Zaretsky, JM; Escuin-Ordinas, H; Garcia-Diaz, A; Hu-Lieskovan, S; Kalbasi, A; Grasso, CS; Hugo, W; Sandoval, S; Torrejon, DY; Palaskas, N; Abril-Rodriguez, G; Parisi, G; Azhdam, A; Chmielowski, B; Cherry, G; Seja, E; Berent-Maoz, B; Shintak

Ribas, A (reprint author), Univ Calif Los Angeles, Dept Med, Div Hematol Oncol, 11-934 Factor Bldg,10833 Le Conte Ave, Los Angeles, CA 90095 USA.

CANCER DISCOVERY, 2017; 7 (2): 188

Abstract

Loss-of-function mutations in JAK1/2 can lead to acquired resistance to anti-programmed death protein 1 (PD-1) therapy. We reasoned that they may also......

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