A short synthesis of Dronedarone

Piotrkowska, B; Nerdinger, S; Schreiner, E; Selic, L; Graczyk, PP

Nerdinger, S (reprint author), Sandoz GmbH, Biochem Str 10, A-6550 Kundl, Austria.

BIOORGANIC & MEDICINAL CHEMISTRY, 2018; 26 (14): 4330

Abstract

A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R = CH2CH2CH2NBu2) in a two-stage pr......

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