Role of endocytosis and trans-endocytosis in ICOS costimulator-induced downmodulation of the ICOS Ligand

Aragoneses-Fenoll, L; Montes-Casado, M; Ojeda, G; Garcia-Paredes, L; Arimura, Y; Yagi, J; Dianzani, U; Portoles, P; Rojo, JM

Portoles, P (corresponding author), Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Inmunol Celular, Ctra Pozuelo Majadahonda,Km 2, E-28220 Madrid, Spain.; Rojo, JM (corresponding author), CSIC, Ctr Invest Biol Margarita Salas, Dept Biomed Mol, Ramiro de Maeztu 9, E-28040 Madrid, Spain.

JOURNAL OF LEUKOCYTE BIOLOGY, ; ():

Abstract

The interaction between the T-lymphocyte costimulatory molecule ICOS and its ligand (ICOS-L) is needed for efficient immune responses, but expression ......

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