Preclinical discovery and clinical development of encorafenib for the treatment of melanoma

Okten, IN; Ismail, S; Withycombe, BM; Eroglu, Z

Eroglu, Z (corresponding author), Univ S Florida, Morsani Sch Med, Dept Oncol Sci, Moffitt Canc Ctr,Cutaneous Oncol Program, Tampa, FL 33620 USA.

EXPERT OPINION ON DRUG DISCOVERY, 2020; 15 (12): 1373

Abstract

Introduction Nearly 50% of patients with metastatic melanoma harbor a BRAFV600-mutation, which can be targeted with the use of BRAF and MEK inhibitors......

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