Structural dynamics and kinase inhibitory activity of three generations of tyrosine kinase inhibitors against wild-type, L858R/T790M, and L858R/ T790M/C797S forms of EGFR

Todsaporn, D; Mahalapbutr, P; Poo-arporn, RP; Choowongkomon, K; Rungrotmongkol, T

Rungrotmongkol, T (通讯作者)，Chulalongkorn Univ, Fac Sci, Ctr Excellence Biocatalyst & Sustainable Biotechno, Dept Biochem, Bangkok 10330, Thailand.;Mahalapbutr, P (通讯作者)，Khon Kaen Univ, Fac Med, Dept Biochem, Khon Kaen 40002, Thailand.;Mahalapbutr, P (通讯作者)，Khon Kaen Univ, Fac Med, Ctr Translat Med, Khon Kaen 40002, Thailand.;Rungrotmongkol, T (通讯作者)，Chulalongkorn Univ, Grad Sch, Program Bioinformat & Computat Biol, Bangkok 10330, Thailand.

COMPUTERS IN BIOLOGY AND MEDICINE, 2022; 147 ():

Abstract

Mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR), including L858R/T790M double and L858R/T790M/C797S triple mutation......

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