Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme

Marbach-Breitruck, E; Kutzner, L; Rothe, M; Gurke, R; Schreiber, Y; Reddanna, P; Schebb, NH; Stehling, S; Wieler, LH; Heydeck, D; Kuhn, H

Kuhn, H (corresponding author), Charite Univ Med Berlin, Inst Biochem, Virchowweg 6,Charitepl 1, D-10117 Berlin, Germany.; Kuhn, H (corresponding author), Free Univ Berlin, Virchowweg 6,Charitepl 1, D-10117 Berlin, Germany.; Kuhn, H (corresponding author), Humboldt Univ, Virchowweg 6,Charitepl 1, D-10117 Berlin, Germany.; Kuhn, H (corresponding author), Berlin Inst Hlth, Virchowweg 6,Charitepl 1, D-10117 Berlin, Germany.

ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (1): 1

Abstract

Aims: Most mammalian genomes involve several genes encoding for functionally distinct arachidonate lipoxygenase (ALOX isoforms). Proinflammatory leuko......

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