Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer

Khawaja, H; Briggs, R; Latimer, CH; Rassel, M; Griffin, D; Hanson, L; Bardelli, A; Di Nicolantonio, F; McDade, SS; Scott, CJ; Lambe, S; Maurya, M; Lindner, AU; Prehn, JHM; Sousa, J; Winnington, C; LaBonte, MJ; Ross, S; Van Schaeybroeck, S

Van Schaeybroeck, S (通讯作者)，Queens Univ Belfast, Patrick G Johnston Ctr Canc Res, Lisburn Rd 97, Belfast BT9 7AE, North Ireland.

MOLECULAR CANCER THERAPEUTICS, 2023; 22 (1): 135

Abstract

Novel covalent inhibitors of KRASG12C have shown limited response rates in patients with KRASG12C-mutant (MT) colorectal cancer. Thus, novel KRASG12C ......

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