Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy

Costantino, S; Akhmedov, A; Melina, G; Mohammed, SA; Othman, A; Ambrosini, S; Wijnen, WJ; Sada, L; Ciavarella, GM; Liberale, L; Tanner, FC; Matter, CM; Hornemann, T; Volpe, M; Mechta-Grigoriou, F; Camici, GG; Sinatra, R; Luscher, TF; Paneni, F

Paneni, F (reprint author), Univ Zurich, Ctr Mol Cardiol, Wagistr 12, CH-8952 Schlieren, Switzerland.; Paneni, F (reprint author), Univ Hosp Zurich, Univ Heart Ctr, Cardiol, Ramistr 100, CH-8091 Zurich, Switzerland.

EUROPEAN HEART JOURNAL, 2019; 40 (12): 997

Abstract

Aims Metabolic cardiomyopathy (MC)characterized by intra-myocardial triglyceride (TG) accumulation and lipotoxic damageis an emerging cause of heart f......

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