Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists

Clark, JC; Martin, EM; Morán, LA; Di, Y; Wang, XQ; Zuidscherwoude, M; Brown, HC; Kavanagh, DM; Hummert, J; Eble, JA; Nieswandt, B; Stegner, D; Pollitt, AY; Herten, DP; Tomlinson, MG; García, A; Watson, SP

Clark, JC; Watson, SP (通讯作者)，Univ Birmingham, Inst Cardiovasc Sci, Coll Med & Dent Sci, Level 1 IBR, Birmingham B15 2TT, England.;Clark, JC; Watson, SP (通讯作者)，Univ Birmingham, Ctr Membrane Prot & Receptors COMPARE, Birmingham, Midlands, England.;Clark, JC; Watson, SP (通讯作者)，Univ Nottingham, Ctr Membrane Prot & Receptors COMPARE, Nottingham, Midlands, England.

COMMUNICATIONS BIOLOGY, 2023; 6 (1):

Abstract

CLEC-2 is a target for a new class of antiplatelet agent. Clustering of CLEC-2 leads to phosphorylation of a cytosolic YxxL and binding of the tandem ......

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