Liver Microvascular Injury and Thrombocytopenia of Antibody-Calicheamicin Conjugates in Cynomolgus Monkeys-Mechanism and Monitoring

Guffroy, M; Falahatpisheh, H; Biddle, K; Kreeger, J; Obert, L; Walters, K; Goldstein, R; Boucher, G; Coskran, T; Reagan, W; Sullivan, D; Huang, CL; Sokolowski, S; Giovanelli, R; Gerber, HP; Finkelstein, M; Khan, N

Guffroy, M (reprint author), Pfizer Inc, Drug Safety Res & Dev, 401 N Middletown Rd, Pearl River, NY 10965 USA.

CLINICAL CANCER RESEARCH, 2017; 23 (7): 1760

Abstract

Purpose: Adverse reactions reported in patients treated with antibody-calicheamicin conjugates such as gemtuzumab ozogamicin (Mylotarg) and inotuzumab......

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