The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Biancucci, M; Minasov, G; Banerjee, A; Herrera, A; Woida, PJ; Kieffer, MB; Bindu, L; Abreu-Blanco, M; Anderson, WF; Gaponenko, V; Stephen, AG; Holderfield, M; Satchell, KJF

Satchell, KJF (reprint author), Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA.; Satchell, KJF (reprint author), Northwestern Univ, Feinberg Sch Med, Ctr Struct Genom Infect Dis, Chicago, IL 60611 USA.

SCIENCE SIGNALING, 2018; 11 (550):

Abstract

The Ras-extracellular signal-regulated kinase pathway is critical for controlling cell proliferation, and its aberrant activation drives the growth of......

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