Bis(benzonitrile) dichloroplatinum (II) interrupts PD-1/PD-L1 interaction by binding to PD-1

Wang, RN; Yu, Q; Wang, XB; Zhu, D; Li, GL; Li, ZX; Jiang, W; Li, W; Dang, YJ

Jiang, W; Dang, YJ (通讯作者)，Fudan Univ, Shanghai Med Coll, Sch Basic Med Sci, Dept Biochem & Mol Biol,Key Lab Metab & Mol Med,Mi, Shanghai 200032, Peoples R China.;Li, W (通讯作者)，China Pharmaceut Univ, Dept Med Chem, Nanjing 211198, Peoples R China.;Dang, YJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Life Sci, Ctr Novel Target & Therapeut Intervent, Chongqing 400016, Peoples R China.

ACTA PHARMACOLOGICA SINICA, 2023; 44 (10): 2103

Abstract

Checkpoint inhibitors such as PD-1/PD-L1 antibody therapeutics are a promising option for the treatment of multiple cancers. Due to the inherent limit......

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