Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells

Mercado-Matos, J; Clark, JL; Piper, AJ; Janusis, J; Shaw, LM

Shaw, LM (reprint author), Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, 364 Plantat St,LRB 409, Worcester, MA 01605 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017; 292 (19): 7806

Abstract

The insulin receptor substrate (IRS) proteins serve as essential signaling intermediates for the activation of PI3K by both the insulin-like growth fa......

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