Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3)

Yamani, A; Zdzalik-Bielecka, D; Lipner, J; Stanczak, A; Piorkowska, N; Stanczak, PS; Olejkowska, P; Hucz-Kalitowska, J; Magdycz, M; Dzwonek, K; Dubiel, K; Lamparska-Przybysz, M; Popiel, D; Pieczykolan, J; Wieczorek, M

Yamani, A (corresponding author), Celon Pharma SA, Med Chem Dept, Mokra 41A, PL-05092 Kielpin, Lomianki, Poland.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 210 ():

Abstract

The FGFR family is characterized by four receptors (FGFR 1-4), binding to 18 ligands called fibroblast growth factors (FGFs). Aberrant activation of F......

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