Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI(2): a safer alternative to COX-2 inhibition

Ozen, G; Gomez, I; Daci, A; Deschildre, C; Boubaya, L; Teskin, O; Uydes-Dogan, BS; Jakobsson, PJ; Longrois, D; Topal, G; Norel, X

Norel, X (reprint author), CHU Xavier Bichat, Eicosanoids & Vasc Pharmacol, LVTS, INSERM,U1148, 46 Rue Huchard, F-75018 Paris, France.

BRITISH JOURNAL OF PHARMACOLOGY, 2017; 174 (22): 4087

Abstract

BACKGROUND AND PURPOSE The side effects of cyclooxygenase-2 (COX-2) inhibitors on the cardiovascular system could be associated with reduced prostagla......

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