Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

Zierden, HC; Ortiz, JI; DeLong, K; Yu, JQ; Li, GS; Dimitrion, P; Bensouda, S; Laney, V; Bailey, A; Anders, NM; Scardina, M; Mahendroo, M; Mesiano, S; Burd, I; Wagner, G; Hanes, J; Ensign, LM

Ensign, LM (corresponding author), Johns Hopkins Univ, Ctr Nanomed, Wilmer Eye Inst, Sch Med, Baltimore, MD 21231 USA.; Ensign, LM (corresponding author), Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA.; Ensign, LM (corresponding author), Johns Hopkins Univ, Wilmer Eye Inst, Dept Ophthalmol, Sch Med, Baltimore, MD 21231 USA.; Ensign, LM (corresponding author), Johns Hopkins Univ, Dept Biomed Engn, Sch Med, Baltimore, MD 21231 USA.; Ensign, LM (corresponding author), Johns H

SCIENCE TRANSLATIONAL MEDICINE, 2021; 13 (576):

Abstract

Inflammation contributes to nearly 4 million global premature births annually. Here, we used a mouse model of intrauterine inflammation to test clinic......

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