Discovery of Axelopran (TD-1211): A Peripherally Restricted mu-Opioid Receptor Antagonist

Long, DD; Armstrong, SR; Beattie, DT; Campbell, CB; Church, TJ; Colson, PJ; Dalziel, SM; Jacobsen, JR; Jiang, L; Obedencio, GP; Rapta, M; Saito, D; Stergiades, I; Tsuruda, PR; Van Dyke, PM; Vickery, RG

Long, DD (reprint author), Theravance Biopharma US Inc, 901 Gateway Blvd, San Francisco, CA 94080 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2019; 10 (12): 1641

Abstract

The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependen......

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