Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations

An, XL; Bai, QF; Bing, ZT; Liu, HX; Yao, XJ

Liu, HX; Yao, XJ (corresponding author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.; Liu, HX; Yao, XJ (corresponding author), Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021; 19 (): 3978

Abstract

Activation of human free fatty acid receptor 1 (FFAR1, also called hGPR40) enhances insulin secretion in a glucose-dependent manner. Hence, the develo......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索