Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-KB/STAT3 and NF-KB/CSN5 signaling pathways

Ruan, ZY; Liang, MH; Shang, L; Lai, MX; Deng, XL; Su, XG

Su, XG (corresponding author), Guangdong Food & Drug Vocat Coll, Sch Pharm, 321 Longdong North Rd, Guangzhou 510520, Guangdong, Peoples R China.; Deng, XL (corresponding author), Guangdong Pharmaceut Univ, Sch Chinese Med, 280 East Ring Rd, Guangzhou 510006, Peoples R China.

PANCREATOLOGY, 2021; 21 (3): 630

Abstract

Background: Pancreatic cancer (PC) is a highly fatal malignancy with few effective therapies currently available. Recent studies have shown that PD-L1......

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