Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells

Bai, ZL; Lundh, S; Kim, D; Woodhouse, S; Barrett, DM; Myers, RM; Grupp, SA; Maus, MV; June, CH; Camara, PG; Melenhorst, JJ; Fan, R

Fan, R (corresponding author), Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA.; Fan, R (corresponding author), Yale Sch Med, Yale Stem Cell Ctr, New Haven, CT 06510 USA.; Fan, R (corresponding author), Yale Sch Med, Yale Canc Ctr, New Haven, CT 06510 USA.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (5):

Abstract

Background Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 molecule have transformed the therapeutic land......

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