Castration Determines the Efficacy of ETAR Blockade in a Mouse Model of Prostate Cancer Bone Metastasis

Moon, HH; Clines, KL; Cooks, MA; Cialek, CA; Esvelt, MA; Clines, GA

Clines, GA (reprint author), Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48109 USA.; Clines, GA (reprint author), Vet Affairs Med Ctr, Ann Arbor, MI 48105 USA.

ENDOCRINOLOGY, 2019; 160 (8): 1786

Abstract

Bone metastasis is a painful complication of advanced prostate cancer. Endothelin-1 is a tumor-secreted factor that plays a central role in osteoblast......

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