N-glycosylation of PD-1 promotes binding of camrelizumab

Liu, KF; Tan, SG; Jin, WJ; Guan, JW; Wang, QL; Sun, H; Qi, JX; Yan, JH; Chai, Y; Wang, ZF; Deng, CX; Gao, GF

Deng, CX; Gao, GF (corresponding author), Univ Macau, Fac Hlth Sci, Macau, Peoples R China.; Tan, SG; Gao, GF (corresponding author), Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China.; Gao, GF (corresponding author), Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China.

EMBO REPORTS, 2020; 21 (12):

Abstract

PD-1 is a highly glycosylated inhibitory receptor expressed mainly on T cells. Targeting ofPD-1 with monoclonal antibodies (MAbs) to block the interac......

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