Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Koach, J; Holien, JK; Massudi, H; Carter, DR; Ciampa, OC; Herath, M; Lim, T; Seneviratne, JA; Milazzo, G; Murray, JE; McCarroll, JA; Liu, B; Mayoh, C; Keenan, B; Stevenson, BW; Gorman, MA; Bell, JL; Doughty, L; Huttelmaier, S; Oberthuer, A; Fischer,

Marshall, GM (reprint author), Sydney Childrens Hosp, Ctr Childrens Canc & Blood Disorders, High St, Randwick, NSW 2031, Australia.; Cheung, BB (reprint author), UNSW Sydney, Childrens Canc Inst Australia, POB 81, Randwick, NSW 2031, Australia.

CANCER RESEARCH, 2019; 79 (21): 5652

Abstract

MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN protein stability is a ......

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