Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC-1 tumor-bearing mice with PD-1 blockade by modulating macrophage heterogeneity and the activation of CD8(+) T cells in the tumor microenvironment-MedSci.cn

Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC-1 tumor-bearing mice with PD-1 blockade by modulating macrophage heterogeneity and the activation of CD8(+) T cells in the tumor microenvironment

Ni, GY; Yang, XD; Li, JJ; Wu, XL; Liu, Y; Li, HJ; Chen, S; Fogarty, CE; Frazer, IH; Chen, GQ; Liu, XS; Wang, TF

Liu, XS (corresponding author), First Peoples Hosp Foshan, Canc Res Inst, Foshan 528000, Guangdong, Peoples R China.; Wang, TF (corresponding author), Univ Sunshine Coast, Genecol Res Ctr, Maroochydore, Qld 4558, Australia.

Abstract

Objectives Developing a vaccine formula that alters the tumor-infiltrating lymphocytes to be more immune active against a tumor is key to the improvem......

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Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC-1 tumor-bearing mice with PD-1 blockade by modulating macrophage heterogeneity and the activation of CD8(+) T cells in the tumor microenvironment

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