SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors

Wang, XM; Chen, ZQ; Xu, J; Tang, S; An, N; Jiang, L; Zhang, YX; Zhang, SY; Zhang, QL; Shen, YY; Chen, SJ; Lan, XJ; Wang, T; Zhai, LH; Cao, SYW; Guo, SQ; Liu, YL; Bi, AW; Chen, YH; Gai, XM; Duan, YC; Zheng, Y; Fu, YX; Li, YZ; Yuan, L; Tong, LJ; Mo, K; Wang, MC; Lin, SH; Tan, MJ; Luo, C; Chen, Y; Liu, J; Zhang, QS; Li, LP; Huang, M

Huang, M (通讯作者),Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China.;Huang, M (通讯作者),Univ Chinese Acad Sci, Beijing, Peoples R China.;Huang, M (通讯作者),Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Jiangsu, Peoples R China.;Huang, M (通讯作者),Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou, Zhejiang, Peoples R China.

CELL RESEARCH, 2022; 32 (7): 638

Abstract

Mutant isocitrate dehydrogenase 1 (mIDH1) drives tumorigenesis via producing oncometabolite R-2-hydroxyglutarate (R-2-HG) across various tumor types. ......

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