Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia

Sun, ZP; Wang, LQ; Han, L; Wang, Y; Zhou, Y; Li, Q; Wu, YQ; Talabieke, S; Hou, YL; Wu, LL; Liu, RH; Fu, ZP; You, HJ; Li, BY; Zheng, YY; Luo, DL

Luo, DL (corresponding author), Capital Med Univ, Sch Basic Med Sci, Dept Pharmacol, St Youanmenwai,10 Xitoutiao, Beijing 100069, Peoples R China.

CIRCULATION, 2021; 144 (10): 788

Abstract

Background: Calsequestrins (Casqs), comprising the Casq1 and Casq2 isoforms, buffer Ca2+ and regulate its release in the sarcoplasmic reticulum of ske......

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