Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

Clark, SJ; Argelaguet, R; Lohoff, T; Krueger, F; Drage, D; Gottgens, B; Marioni, JC; Nichols, J; Reik, W

Clark, SJ; Argelaguet, R; Reik, W (通讯作者)，Babraham Inst, Epigenet Programme, Cambridge CB22 3AT, England.;Clark, SJ; Argelaguet, R; Reik, W (通讯作者)，Cambridge Inst Sci, Altos Labs, Granta Pk, Cambridge, England.;Reik, W (通讯作者)，Univ Cambridge, Jeffrey Cheah Biomed Ctr, Wellcome Trust, MRC,Stem Cell Inst, Puddicombe Way, Cambridge, England.;Reik, W (通讯作者)，Wellcome Sanger Inst, Wellcome Genome Campus, Cambridge, England.;Reik, W (通讯作者)，Univ Cambridge, Ctr Trophoblast Res, Cambridge, Scotland.

GENOME BIOLOGY, 2022; 23 (1):

Abstract

Background: Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosi......

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