One-step generation of modular CAR-T cells with AAV-Cpf1

Dai, XY; Park, JJ; Du, YY; Kim, HR; Wang, GC; Errami, Y; Chen, SD

Chen, SD (reprint author), Yale Univ, Syst Biol Inst, West Haven, CT 06516 USA.; Chen, SD (reprint author), Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA.; Chen, SD (reprint author), Yale Univ, Integrated Sci & Technol Ctr, Ctr Canc Syst Biol, W

NATURE METHODS, 2019; 16 (3): 247

Abstract

Immune-cell engineering opens new capabilities for fundamental immunology research and immunotherapy. We developed a system for efficient generation o......

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