TRIB3 reduces CD8(+) T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer

Shang, S; Yang, YW; Chen, F; Yu, L; Shen, SH; Li, K; Cui, B; Lv, XX; Zhang, C; Yang, C; Liu, J; Yu, JJ; Zhang, XW; Li, PP; Zhu, ST; Zhang, HZ; Hua, F

Hua, F (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Immunol & Canc Pharmacol Grp, Beijing 100050, Peoples R China.;Zhang, HZ (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Dept Colorectal Surg, State Key Lab Mol Oncol, Natl Canc Ctr,Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100021, Peoples R China.

SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (626):

Abstract

High CD8(+) T cell infiltration in colorectal cancer (CRC) should suggest a favorable prognosis and a satisfactory response to immunotherapy; however,......

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