Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum

Bhattacharya, A; Leprohon, P; Ouellette, M

Ouellette, M (corresponding author), CHU Quebec, Axe Malad Infect & Immunitaires, Ctr Rech, Ctr Rech Infectiol, Quebec City, PQ, Canada.

PLOS NEGLECTED TROPICAL DISEASES, 2021; 15 (4):

Abstract

Our understanding of folate metabolism in Leishmania has greatly benefited from studies of resistance to the inhibitor methotrexate (MTX). Folates are......

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