Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment

Yang, HJ; Chen, X; Li, K; Cheaito, H; Yang, QQ; Wu, GJ; Liu, JB; Dou, QP

Dou, QP (corresponding author), Wayne State Univ, Barbara Ann Karmanos Canc Inst, Sch Med, Dept Oncol, Detroit, MI 48201 USA.; Dou, QP (corresponding author), Wayne State Univ, Barbara Ann Karmanos Canc Inst, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA.; Dou, QP (corresponding author), Wayne State Univ, Barbara Ann Karmanos Canc Inst, Sch Med, Dept Pathol, Detroit, MI 48201 USA.

SEMINARS IN CANCER BIOLOGY, 2021; 68 (): 105

Abstract

The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated a......

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