Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities

Ding, ZP; Hou, YW; Wang, SX; Sun, TW; Ma, MX; Guan, HS; Li, WB

Li, WB (reprint author), Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China.; Li, WB (reprint author), Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China.

MOLECULAR DIVERSITY, 2017; 21 (3): 577

Abstract

Deuterium-enriched and fluorine-substituted compounds have been widely applied in drug discovery due to their advantages in the studies of clinical ph......

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