The return of RET GateKeeper mutations? an in-silico exploratory analysis of potential resistance mechanisms to novel RET macrocyclic inhibitor TPX-0046

Repetto, M; Crimini, E; Ascione, L; Bielo, LB; Belli, C; Curigliano, G

Curigliano, G (通讯作者),European Inst Oncol IRCCS, Div Early Drug Dev Innovat Therapies, Milan, Italy.;Curigliano, G (通讯作者),Univ Milan, Dept Oncol & Hematooncol, Milan, Italy.

INVESTIGATIONAL NEW DRUGS, 2022; 40 (5): 1133

Abstract

TPX-0046 is designed to overcome resistance to FDA approved RET inhibitors Selpercatinib and Pralsetinib. Early prediction of resistance mechanisms to......

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